Francisco Leonelli replaces Webster on the left wing while Rory Lawson comes in for Mike Blair at scrum-half. In the front row, Alasdair Dickinson switches from loosehead to tighthead and is joined by Allan Jacobsen. Dave Duley starts in the second row while Alasdair Strokosch replaces Hogg at openside flanker.
Blackadder said: "We are looking forward to this game. We're keen to build on last week's performance against Llanelli - which I was very proud of.
"Connacht are a tough side, especially at home. They'll battle hard even though they are at the bottom of the league and they won't lie down. We have to play the sort of rugby we are capable of and it's important for us to match them physically," he added.
Edinburgh Gunners team:
15 Hugo Southwell; 14 Chris Paterson CAPTAIN, 13 Marcus Di Rollo, 12 Peter Jorgensen, 11 Francisco Leonelli; 10 Phil Godman, 9 Rory Lawson,1 Allan Jacobsen, 2 Andrew Kelly, 3 Alasdair Dickinson; 4 Alastair Kellock, 5 Dave Duley; 6 Matt Mustchin, 8 Simon Taylor, 7 Alasdair Strokosch *
Substitutes 16 Kyle Traynor 17 Dave Hewett 18 Fergus Pringle 19 Alan MacDonald 20 Mike Blair 21 Ander Monro 22 Michael Pyke