In the pack, vice-captain Scott Murray returns in the second row for Dave Duley and Dave Callam takes the No 8 jersey in place of Simon Taylor who has been forced out for at least four months with medial ligament damage.
Blackadder said: "This game provides a huge challenge after a good away win over Connacht last weekend and we're looking to back it up with another. The mind set amongst the players is to get down there and play good rugby, the type we are capable of.
"We did that in the second half last week and we want to replicate it tomorrow. If we do we are virtually unstoppable. We are motivated to perform and the players are focused on a strong finish," he added.
Edinburgh Gunners team: 15 Hugo Southwell; 14 Chris Paterson CAPTAIN, 13 Peter Jorgensen, 12 Matt Dey, 11 Simon Webster; 10 Ander Monro, 9 Rory Lawson; 1 Allan Jacobsen, 2 Andrew Kelly, 3 Alasdair Dickinson, 4 Alastair Kellock; 5 Scott Murray, 6 Matt Mustchin, 8 Dave Callam, 7 Alasdair Strokosch
Substitutes:16 Kyle Traynor, 17 Craig Smith, 18 Fergus Pringle, 19 Ross Rennie, 20 Mike Blair, 21 Phil Godman, 22 Francisco Leonelli
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