The players come in for Sean Lamont, Dan Parks, Scott Lawson, Bruce Douglas, Scott Murray and Donnie Macfadyen respectively.
On the bench coach Frank Hadden has opted for five forwards and two backs.
Hadden explained the rationale behind his selection. "Our first priority is to win the Test match this weekend and there are also things we need to look at from the World Cup perspective, such as the blend of the side and what individuals can do.
"Last week's group had the opportunity to do something special. Now that chance falls to the team for this week."
Lamont was available for selection but Hadden decided not to include him following the leg injury he sustained at the ABSA Stadium, while the selection of his pack reflects a desire to stand "toe to toe" with the physicality of the Springboks.
Scotland team: 15 Hugo Southwell (Edinburgh Gunners); 14 Chris Paterson (Edinburgh Gunners), 13 Marcus Di Rollo (Edinburgh Gunners), 12 Andrew Henderson (Glasgow Warriors), 11 Simon Webster (Edinburgh Gunners); 10 Gordon Ross (Leeds Tykes), 9 Mike Blair (Edinburgh Gunners); 1 Gavin Kerr (Leeds Tykes), 2 Dougie Hall (Edinburgh Gunners), 3 Craig Smith (Edinburgh Gunners); 4 Nathan Hines (Perpignan), 5 Alastair Kellock (Edinburgh Gunners); 6 Jason White (Sale Sharks) CAPTAIN, 8 Jon Petrie (Glasgow Warriors), 7 Allister Hogg (Edinburgh Gunners)
Substitutes:16 Scott Lawson (Glasgow Warriors), 17 Bruce Douglas (Border Reivers), 18 Scott MacLeod (Border Reivers), 19 Kelly Brown (Border Reivers), 20 Donnie Macfadyen (Glasgow Warriors), 21 Sam Pinder (Glasgow Warriors), 22 Ben MacDougall (Border Reivers)
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