And after disappointing showings in the Heineken Cup, both Scottish sides have now lost four from four in their respective Pools, the derby represents a chance to claim local bragging rights.
Gregor Townsend's Glasgow, currently fifth in the RaboDirect PRO12 table, are two positions and seven points ahead of Michael Bradley's Edinburgh.
And Hastings, Scotland's record points scorer until Chris Paterson overtook him in 2008, is looking forward to seeing the Scots bounce back in style this weekend.
"On the back of a very disappointing series of internationals, these matches are going to assume huge importance," he said.
"They will be almost like trial matches. The inter-city clash has been a huge boost to the rugby calendar, the Scottish public has taken to these matches.
"A few years ago Dan Parks completely outplayed his opposite number Phil Godman.
"And, for me, it was absolutely right that Dan went on to represent Scotland in the Six Nations.
"Whoever plays best in the head-to-heads, that player should be selected and the players will take these games very seriously indeed.
"It's a bit like way back in the dim and distant past when we always had the national trial early in the New Year and got fantastic crowds."
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