Muldoon, who had been out of action since playing against Edinburgh in October, is a major boost ahead of the second derby of the season to be played in Galway.
In all there are five changes to the side which beat Rugby Rovigo last time out before Christmas. Liam Bibo has recovered from a hamstring injury to start on the left wing while Niva Ta'auso will make his first start at outside centre.
Up front Sean Cronin starts at hooker while Colm Rigney returns at number eight.
Connacht team: G Duffy; T Nathan, N Ta'auso, K Matthews, L Bibo; I Keatley, F Murphy; B Wilkinson, S Cronin, R Morris; M McCarthy, A Farley; J Muldoon (C), R Ofisa, C Rigney
Replacements: (7 from 8) A Flavin, R Loughney, A Browne, M Swift, K Campbell, A Dunne, M Deane, F Carr
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland
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