Brian O'Driscoll returns to captain the side after missing last week's 29-0 victory over Ulster and will partner Felipe Contepomi at centre, with Jonathan Sexton continuing at out-half after impressing in that win.
Sexton will be partnered by Chris Keane at half-back while the other change in the back-line sees Gary Brown start on the right wing in place of Rob Kearney who picked up a slight knock in training during the week.
In the pack, Brian Blaney starts at hooker and lines up alongside Cian Healy and Stan Wright in the front row. Cameron Jowitt partners Malcolm O'Kelly in the second row, while Shane Jennings starts in the back-row alongside Stephen Keogh and Jamie Heaslip.
Gordon D'Arcy is one of five Ireland internationals named on the league leaders' bench alongside Guy Easterby, Keith Gleeson, Bernard Jackman and Trevor Hogan who returns to the squad for the first time since suffering a knee injury three months ago.
Over 13,000 tickets have been sold for Saturday's game and tickets are on sale from www.leinsterrugby.ie, Ticketmaster outlets nationwide, Spar in Donnybrook and the Leinster Rugby Store. Tickets will be available from Ticketmaster booths on Simmonscourt Road and Anglesea Road from 5pm on Saturday.
LEINSTER:
15: Girvan Dempsey
14: Gary Brown
13: Brian O'Driscoll CAPTAIN
12: Felipe Contepomi
11: Luke Fitzgerald
10: Jonathan Sexton
9: Chris Keane
1: Cian Healy
2: Brian Blaney
3: Stan Wright
4: Cameron Jowitt
5: Malcolm O'Kelly
6: Stephen Keogh
7: Shane Jennings
8: Jamie Heaslip
REPLACEMENTS:
16: Bernard Jackman
17: Stephen Knoop
18: Trevor Hogan
19: Keith Gleeson
20: Guy Easterby
21: Gordon D'Arcy
22: Christian Warner
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland