Isa Nacewa will make his debut for the province after being named in an unchanged line-up from the side that started last weekend's 48-19 friendly victory over the Queensland Reds.
Nacewa is named in a backline that includes Brian O'Driscoll and Felipe Contepomi who will resume their centre partnership. Ireland internationals Shane Horgan and Rob Kearney have been named on either wing. Chris Whitaker captains the side.
In the pack, Cameron Jowitt is named in a dynamic-looking back-row alongside Ireland internationals Shane Jennings and number eight Jamie Heaslip.
Meanwhile, Leinster Academy graduate Sean O'Brien could be one of two potential debutants should he be called upon in the Welsh capital alongside summer signing - and former Ireland 'A' captain - John Fogarty. Prop Stephen Knoop has recovered from illness to take his place on the strong replacements bench which includes Ireland trio Trevor Hogan, Luke Fitzgerald and Girvan Dempsey.
LEINSTER:
15: Isa Nacewa
14: Shane Horgan
13: Brian O'Driscoll
12: Felipe Contepomi
11: Rob Kearney
10: Jonathan Sexton
9: Chris Whitaker CAPTAIN
1: Cian Healy
2: Bernard Jackman
3: Ronan McCormack
4: Devin Toner
5: Malcolm O'Kelly
6: Cameron Jowitt
7: Shane Jennings
8: Jamie Heaslip
REPLACEMENTS:
16: John Fogarty
17: Stephen Knoop
18: Trevor Hogan
19: Sean O'Brien
20: Chris Keane
21: Luke Fitzgerald
22: Girvan Dempsey
Speaking ahead of the Saturday evening's opening clash of the Magners League season, Leinster scrum-half CHRIS WHITAKER believes that the squad are in good shape as they travel to face the Cardiff Blues:
"Pre season has gone quite well and the squad are in good shape coming into Saturday's game. We got away for a week to Italy which was important because as well as the squad being fitter and stronger, I think off the field we're a lot tighter as a unit.
"There's no doubting that the Cardiff game will be a big test. They have a good strong forward pack who are very physical, but they also have a lot of very fast and mobile backs that like to take the ball on. We can't afford to ease into the game because there will be a massive increase in terms of intensity from our three warm-up games.
At this time of year, and with places up for grabs, there's naturally a bit of nervousness in the squad. But that's a good thing because it means that everyone is focused on getting one of the starting 15 shirts. There's more depth in all positions this year and I believe that we're going into this new season with the strongest panel we've had since I arrived.
"There's a real intensity in the squad's preparations. The physicality and desire to improve bodes well and the key thing is getting off to a good start.
"Last weekend was my first real hit out, and fitness wise I feel that things are coming along nicely. We're all helping each other out and there has been a real team emphasis in training. Even though we're all competing for spots, the scrum-halves are always staying behind after training to help each other out. And that applies also to the hookers and the various other specialist positions in the squad.
"It is a big honour to lead the team in Leo's (Cullen) absence, but being captain doesn't change how I play or how I approach the game. With so many leaders in our squad everyone takes on their own individual responsibility during games, so the emphasis on the role of the captain has diminished over the years.
"On a personal level I love playing in Wales. The Welsh public are extremely knowledgeable and there's always a bit of banter when you're playing. I'd liken the atmosphere to playing in New Zealand or South Africa where rugby is the number one sport. That fanaticism can really inspire you and I'm sure we'll have a strong contingent over from Ireland to cheer us on also."
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