In the backline Troy Nathan comes into the side at fullback, Kieran Campbell gets his first competitive start for the province at scrum half and Aidan Wynne starts on the left wing.
In the forwards Adrian Flavin gets his first start of the season at hooker and he is partnered at tighthead by Ronan Loughney while Michael Swift comes into the side in the second row.
Captain John Muldoon reverts back to number eight while Michael McCarthy moves to blindside flanker.
Connacht team:
T Nathan; F Carr, G Duffy, K Matthews, A Wynne; I Keatley, K Campbell; B Wilkinson, A Flavin, R Loughney; M Swift, A Farley; M McCarthy, R Ofisa, J Muldoon (C).
Replacements: S Cronin, B McGovern, A Browne, C Rigney, F Murphy, M Deane, L Bibo.
Not considered due to injury: Tim Donnelly (shoulder), John Hearty (groin), Robbie Morris (arm), Johnny O'Connor (arm), Conor O'Loughlin (hip), Daniel Riordan (hamstring), Michael Roberts (calf).
Guinness PRO12
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