D'Arcy will link up at centre with Brian O'Driscoll who successfully came through his first appearance of the season against the Ospreys last weekend.
Luke Fitzgerald becomes the province's 18th player to reach the 100-cap mark and he forms a back three alongside Isa Nacewa (who makes his 96th appearance) and the returning Rob Kearney, with Eoin Reddan partnering Jonathan Sexton at half back.
Naas number eight Jamie Heaslip captain's the team and he forms an all Irish back-row alongside Shane Jennings and Kevin McLaughlin.
Brad Thorn locks down alongside Devin Toner while up front Heinke van der Merwe is named in the front row alongside Sean Cronin and Mike Ross.
Leo Cullen, Cian Healy and Sean O'Brien are named amongst the replacements.
LEINSTER:
15: Rob Kearney
14: Isa Nacewa
13: Brian O'Driscoll
12: Gordon D'Arcy
11: Luke Fitzgerald
10: Jonathan Sexton
9: Eoin Reddan
1: Heinke van der Merwe
2: Sean Cronin
3: Mike Ross
4: Brad Thorn
5: Devin Toner
6: Kevin McLaughlin
7: Shane Jennings
8: Jamie Heaslip CAPTAIN
REPLACEMENTS:
16: Richardt Strauss
17: Cian Healy
18: Jamie Hagan
19: Leo Cullen
20: Sean O'Brien
21: Isaac Boss
22: Ian Madigan
23: Fergus McFadden
REFEREE: Nigel Owens (WRU), ASSISTANT REFEREES: David Wilkinson, Michael Black (IRFU), TMO: Marshall Kilgore (IRFU)