The fifth change sees Marcus Horan get the nod over Wian du Preez at loose-head prop.
The absence of Hurley affords McGahan the opportunity to re-install Felix Jones at full-back, Jones looked sharp when he came on as a 60th minute replacement in Treviso and Tommy O'Donnell who returned from injury in the 68th minute of that game, takes over on the openside from O'Mahony.
Ian Keatley who missed out on the trip to Italy after twisting an ankle, wears the number 10 shirt and Billy Holland operates alongside skipper Mick O'Driscoll in the second row
Munster: F Jones; J Murphy, D Barnes, L Mafi, S Zebo; I Keatley, T O'Leary; M Horan, D Varley, BJ Botha; B Holland, M O'Driscoll capt; Dave O'Callaghan, T O'Donnell, J Coughlan. Replacements: D Fogarty, W du Preez, S Archer, D Foley, P Butler, D Williams, S Deasy, L O'Dea.
Referee: Leighton Hodges (WRU).