The squad sees 8 changes from the side that defeated Leinster on Wednesday.
Liam Bibo, Tiernan O'Halloran, Eoin Griffin, Ray Ofisa, David Nolan, Dermot Murphy, Conor Higgins and Eoin McKeown have been called up to the side.
Connacht will be looking to continue their recent good form and complete the double over the Welsh side having beaten them 16 - 10 when they visited the Sportsground back in October.
Connacht (squad):
Backs from:
Liam Bibo
Kieran Campbell
Eoin Griffin
Ian Keatley
Troy Nathan
Miah Nikora
Tiernan O'Halloran
Conor O'Loughlin
Brian Tuohy
Aidan Wynne
Forwards from:
Andrew Browne
Adrian Flavin
Conor Higgins
Ronan Loughney
Mike McComish
Eoin McKeown
Robbie Morris
Dermot Murphy
Dave Nolan
Johnny O'Connor
Ray Ofisa
Bernie Upton
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