International maori winger Joe Maddock will make his debut with the Benetton jersey after his move from Bath this summer.
With captain Antonio Pavanello still injured, the position will be taken by Leonardo Ghiraldini, former italian captain during the last Six Nations campaign.
Ignacio Fernandez Rouyet, Lorenzo Cittadini and Valerio Bernabò will all start from the beginning, while the italian international Franco Sbaraglini will be on the bench for the first time since his long recovery.
Here is the team:
15 Brendan Williams
14 Joseph Maddock
13 Tommaso Benvenuti
12 Alberto Sgarbi
11 Luke McLean
10 Kristopher Burton
9 Tobias Botes
8 Manoa Vosawai
7 Alessandro Zanni
6 Robert Barbieri
5 Corniel Van Zyl
4 Valerio Bernabò
3 Lorenzo Cittadini
2 Leonardo Ghiraldini (captain)
1 Ignacio Fernandez Rouyet
Replacements
16 Diego Vidal
17 Franco Sbaraglini
18 Pedro Di Santo
19 Enrico Pavanello
20 Paul Derbyshire
21 Ezio Galon
22 Fabio Semenzato
23 Simon Picone