Jamie Heaslip forms a back-row partnership with O'Brien and Dominic Ryan, with Scotland international second-row Nathan Hines partnering O'Donoghue at second row.
Shane Horgan links up in an exciting back three with Luke Fitzgerald and Niall Morris. New signing Ben Prescott has been amongst the replacements alongside Ireland hooker John Fogarty.
LEINSTER:
15: Luke Fitzgerald
14: Shane Horgan
13: Eoin O'Malley
12: Fergus McFadden
11: Niall Morris
10: Isa Nacewa
9: Isaac Boss
1: Heinke van der Merwe
2: Richardt Strauss
3: Simon Shawe
4: Nathan Hines
5: Ed O'Donoghue
6: Dominic Ryan
7: Sean O'Brien CAPTAIN
8: Jamie Heaslip
REPLACEMENTS:
16: John Fogarty
17: Jack McGrath
18: Ben Prescott
19: Mariano Galarza
20: Stephen Keogh
21: Paul O'Donohoe
22: Ian Madigan
23: Eamonn Sheridan
Speaking ahead of Friday night's Magners League opener, Leinster and Scotland second-row Nathan Hines said:
"Glasgow will be strong. In saying that they do have a few absentees such as Alistair Kellock, Chris Cusiter and (Johnnie) Beattie, while Kelly Brown has gone to Saracens. With that, it presents another opportunity for the younger guys to come through and try to claim a scalp. Us, we finished top of the table last year and it's their first home game so there's pretty much everything to play for even though they haven't got their strongest team.
"It's going to be a tough season for them when you have guys away with Scotland, and (having) some of the other guys injured. I think it's good that they have some young guys coming through and getting experience in the Magners League, but it's hard to say how good they are until they're tried and tested.
"They have some good players. Max Evans is threatening out wide. (Bernardo) Stortoni is solid under the high ball at full-back and Richie Vernon, the ex-Sevens player who plays in the back-row, is quick and runs good lines.
"It's quite difficult to analyse teams at this time of year. In my department we try to look at lineouts and try and work out how weak sides are in certain areas, but obviously we haven't much to go on so it's a bit like backyard footy!
"The two pre-season games (that we had) were good preparation for the start of the League proper and obviously they count, but you're not playing for points in pre-season. Historically we haven't done very well in Glasgow so it's an opportunity for everyone to get a scalp early on.
"Leicester was an improved performance compared to how we did against Wasps. We would have liked to have made bigger strides forward, but as long as we go to Glasgow and produce what we can do on the training pitch and come away with a win, then it doesn't really matter what happens in pre-season. Provided we get our campaign on track."
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