Centre Pat Leach who made his regional debut on Sunday has been withdrawn following an ankle injury picked up in the Glasgow game and Dragons player-coach Shaun Connor returns to the side as a replacement as Matthew Jones replaces the injured Jason Tovey.
Following the end of his trial period with the Dragons, centre David Bishop has not been retained by the region.
Dragons Side for Blues
Will Harries, Matthew Pewtner, Tom Riley, Rhodri Gomer Davies, Aled Brew, Matthew Jones; Wayne Evans; Hugh Gustafson, Steve Jones, Ben Castle, Luke Charteris (C), Rob Sidoli, Dan Lydiate, Robin Sowden-Taylor, Gavin Thomas.
Replacements
Lloyd Burns, Nigel Hall, Aaron Coundley, Scott Morgan, Andrew Coombs, Adam Hughes, Nicky Griffiths, Shaun Connor
Absent through Injury
Ashley Smith (foot)
Duane Goodfield (shoulder)
Jason Tovey (Hamstring)
Martyn Thomas (ankle)
Matthew Watkins (Stomach)
Mike Poole (knee)
Nathan Brew (foot)
Nathan Buck (knee)
Toby Faletau (Foot)
Tom Cooper (hamstring)
Tom Willis (rib)