All eyes will be on Benetton's new signing Willem De Waal. The South African played with Western Province in the Currie Cup final and will play as fly half. Kris Burton will be moved to fullback.
Andrea Pratichetti (on his birthday) and Enrico Ceccato will make their appearances in the team for the first time, while lock Valerio Bernabò will play as open side flanker.
Last but not least, Italian international winger Michele Sepe could make his debut in the green and white jersey, starting from the bench.
Here is the team chosen by head coach Franco Smith for the match:
15 Kristopher Burton
14 Ludovico Nitoglia
13 Andrea Pratichetti
12 Gonzalo Garcia
11 Joseph Maddock
10 Willem De Waal
9 Tobias Botes
8 Marco Filippucci
7 Valerio Bernabò
6 Francesco Minto
5 Corniel Van Zyl
4 Antonio Pavanello (captain)
3 Pedro Di Santo
2 Enrico Ceccato
1 Ignacio Fernandez Rouyet
Replacements:
16 Franco Sbaraglini
17 Matteo Muccignat
18 Augusto Allori
19 Enrico Pavanello
20 Gonzalo Padrò
21 Benjamin De Jager
22 Fabio Semenzato
23 Michele Sepe