James Coughlan will lead the side that includes Johne Murphy and Damien Varley who have also been released by the IRFU.
Sam Tuitupou return in the backline after a three week suspension and the front-row sees the Peter Borlase make his debut after arriving from Canterbury.
The replacements include academy players Conor Murray, Mike Sherry and potentially Brian Hayes as McGahan waits on the fitness of Alan Quinlan.
Munster: Johne Murphy, Doug Howlett, Keith Earls, Sam Tuitupou, Denis Hurley, Paul Warwick, Duncan Williams, Wian Du Preez, Damien Varley, Peter Borlase, Billy Holland, Ian Nagle, Peter O'Mahony, Niall Ronan, James Coughlan (Capt.) Replacements: Mike Sherry, Stephen Archer, Alan Quinlan/Brian Hayes, Tommy O'Donnell, Conor Murray, Scott Deasy, Barry Murphy.