That 37-32 triumph at the Parc-y-Scarlets secured a top-four finish and a Play-Off semi-final but a win at the Liberty Stadium would leave them just 80 minutes away from Magners League glory.
Warriors skipper Ali Kellock admits that winning is now all that matters but the Scotland lock knows that won't be easy against the only side Glasgow are yet to beat this season.
"I'll take a win by a point against the Ospreys," said Kellock, who is hoping to become the first captain of a Scottish side to lift the Magners League trophy.
"They're going really well. They've had a great run of form and they're peaking at the right time so it'll be a very tough game.
"They've got a squad to envy. They've probably got 40 top-quality players to pick from but they'll only be allowed 15 on the park and so are we so it'll be a good game.
"It's a semi-final and anything can happen. We'll be looking to go down there and provide what would be an upset by getting a result."
Glasgow did all they could to secure a home semi-final by leaving Llanelli with maximum points last weekend but the Ospreys matched them with their demolition of the Dragons.
Anything less than five points for the Ospreys in Round 18 could have seen the Play-Off take place in Glasgow but Kellock says his side aren't giving too much thought to the disadvantages often associated with playing away from home.
"We talk a lot about what it is to come away from home," added Kellock.
"We're still playing the same game on the same park. Hopefully, we'll get a good travelling support and they can make as much noise as they've been making at Firhill in recent weeks."
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