The Scottish side are one of three teams vying for the fourth and final place in the next weekend's semi-finals and are looking to build on their runners-up spot to Munster to last year's straight league competition.
Five points will get them into the last four if Cardiff Blues beat Munster without a bonus point and deny the defending champions a point at the Cardiff City Stadium. A win without a bonus point would leave them dependent on other results - and requiring a mathematical miracle to qualify.
Moffat has made five changes to the side that went down 37-25 at home to Ulster in their last outing. Significantly, he has been able to recall back row man Ali Hogg who has now fully recovered from a hip operation.
"We know what we have to do this weekend and the teams who finish in the top four and qualify for the play-offs are those who deserve to be there on their form over the whole season," said Moffat
"We know we are capable of getting five points from the game in Dublin and that is not said without any disrespect to Leinster, who are among the best teams in Europe and who will be hurting at their Heineken defeat last weekend.
"It's said from the fact that when we play to the best of our ability we can beat the best teams in Europe - just as we have against Stade Francais, the Ospreys, Bath and Munster this season."
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland