Webster, who scored the winning try in the 32-31 win over London Wasps in the Gunners' last home match in this competition, will replace Argentinean international Francisco Leonelli who has been forced out with a groin strain. Canadian international Michael Pyke will replace Webster on the bench.
Edinburgh Gunners' interim head coach Todd Blackadder said: "Francisco's injury is nothing too serious but we've decided to bring Simon Webster into the starting line. He is on fire at the moment so I don't feel we've lost anything with the switch. It also gives Mike Pyke a chance to play in his first Heineken Cup game."
Edinburgh Gunners team: Hugo Southwell, Chris Paterson Captain, Marcus Di Rollo, Peter Jorgensen, Simon Webster; Phil Godman, Mike Blair; Dave Hewett, Dougie Hall, Craig Smith, Fergus Pringle, Scott Murray, Matt Mustchin, Simon Taylor, Allister Hogg
Substitutes: Andrew Kelly, Allan Jacobsen, Simon Cross, Alasdair Strokosch, Rory Lawson, Michael Pyke, Matt Dey
Guinness PRO12
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