It shows two changes to the side which defeated Montpellier in the Amlina Challenge Cup.
Sean Cronin takes over from Adrian Flavin at hooker, while Ian Keatley starts at out-half with Miah Nikora swapping places on the bench.
Ray Ofisa and Robbie Morris return to the squad and are selected on the bench.
15 Gavin Duffy
14 Troy Nathan
13 Niva Ta'auso
12 Keith Matthews
11 Fionn Carr
10 Ian Keatley
9 Frank Murphy
1 Brett Wilkinson
2 Sean Cronin
3 Jamie Hagan
4 Michael Swift
5 Bernie Upton
6 Michael McCarthy
7 Johnny O'Connor
8 John Muldoon (captain)
16 Adrian Flavin
17 Robbie Morris
18 Andrew Browne
19 Ray Ofisa
20 Conor O'Loughlin
21 Miah Nikora
22 Tiernan O'Halloran
Guinness PRO12
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